906540-99-6

Upstream product

• 681179-07-7 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonitrile 

Downstream Products

• 906541-03-5 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N'-[(2,2-dimethylpropanoyl)oxy]-4-methyl-1H-pyrazole-3-carboximidamide 
• 906541-05-7 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N'-[(3-phenylpropanoyl)oxy]-1H-pyrazole-3-carboximidamide 
• 906541-07-9 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N'-[[3-(2-thienyl)propanoyl]oxy]-1H-pyrazole-3-carboximidamide 
• 1080662-65-2 3-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-5-(trifluoromethyl)-1,2,4-oxadiazole 
• 1016556-11-8 3-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-5-(pentan-3-yl)-1,2,4-oxadiazole 
• 1080662-62-9 3-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-5-ethyl-1,2,4-oxadiazole 
• 1080662-61-8 3-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-5-methyl-1,2,4-oxadiazole 
• 1016556-18-5 3-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-5-isopropyl-1,2,4-oxadiazole 
• 1080662-64-1 3-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-5-propyl-1,2,4-oxadiazole 

Relevant academic research and scientific papers

Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists

Based on the bioisosteric replacement of the pyrazole C3-carboxamide of rimonabant with a 5-alkyl oxadiazole ring, a novel class of oxadiazole derivatives with promising biological activity towards CB1 receptors was discovered. Among them, compounds with an alkyl linker containing a strong electron-withdrawing group (e.g., CF3) and a sterically favorable bulky group (e.g., t-butyl) exhibited excellent CB1 antagonism and selectivity, and thus might serve as potential candidates for further development as anti-obesity agents.

(1,5-DIPHENYL-1H-PYRAZOL-3-YL)OXADIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS

The invention relates to compounds having formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to a method of preparing said compounds and to the application thereof in therapeutics.