906543-68-8Relevant academic research and scientific papers
Convenient synthesis of some 4′-methtylthio-containing aryl and arylfuryl pyrazolines and their antimicrobial activity studies
Holla, Bantwal Shivarama,Mahalinga, Manjathuru,Ashok, Mithun,Karegoudar, Prakash
, p. 1427 - 1436 (2007/10/03)
The condensation of 4-acetylthioanisole with different aryl and aryfuryl aldehydes under aldol conditions affords α, β-unsaturated ketones (propenones), which undergo a facile and clean cyclization with hydrazines to give pyrazolines (4-6) in quantitative yields. The structures of newly synthesized compounds have been confirmed on the basis of spectral studies. All newly synthesized compounds were tested for their antibacterial and antifungal activity. Copyright Taylor & Francis Group, LLC.
Synthesis of pyrazolines promoted by Amberlyst-15 catalyst
Holla, B. Shivarama,Mahalinga,Poojary, Boja,Ashok, Mithun,Akberali
, p. 568 - 571 (2007/10/03)
The condensation of a series of aromatic ketones with aromatic aldehydes under aldol conditions affords 1-aryl-3-(substituted-phenyl/phenyl furanyl/thienyl)-2-propen-1-ones 1. The resulting propenones undergo facile and clean cyclization with hydrazine and substituted hydrazine derivatives to yield 3-aryl-5-(substitutedphenyl/phenylfuranyl/thienyl)-2-pyrazolines 2. This reaction is carried out in the presence of Amberlyst-15 catalyst to afford the above pyrazolines 2 in considerably good yield. All the synthesized compounds have been characterized by spectral studies.
