90660-09-6Relevant articles and documents
Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors
Li, Hongmei,Asberom, Theodros,Bara, Thomas A.,Clader, John W.,Greenlee, William J.,Josien, Hubert B.,McBriar, Mark D.,Nomeir, Amin,Pissarnitski, Dmitri A.,Rajagopalan, Murali,Xu, Ruo,Zhao, Zhiqiang,Song, Lixin,Zhang, Lili
, p. 6290 - 6294 (2008/09/17)
Development of cis-2,4,6-trisubstituted piperidine N-arylsulfonamides as γ-secretase inhibitors for the potential treatment of Alzheimer's disease (AD) is reported.
A NOVEL APPROACH TO CHIRAL CYCLOBUTANES- -AN ENANTIOSELECTIVE TOTAL SYNTHESIS OF (+)-(S,Z)-5-(1-DECENYL)DIHYDRO-2(3H)-FURANONE AND (-)-(R,Z)-5-(1-DECENYL)DIHYDRO-2(3H)-FURANONE
Nemoto, Hideo,Ishibashi, Hiroki,Mori, Masahiko,Fujita, Shigekazu,Fukumoto, Keiichiro
, p. 1237 - 1240 (2007/10/02)
An enantioselective synthesis of (+)-(S,Z)-5-(1-decenyl)-dihydro-2(3H)-furanone (25) and (-)-(R,Z)-5-(1-decenyl)dihydro-2(3H)-furanone (26) was achieved starting with either (10) or (11) prepared by reduction of the chiral cyclobutanone (8) which was derived stereospecifically from the cyclopropyl carbinol (6) by ring expansion reaction.