906623-17-4

Upstream product

• 7463-51-6 4-bromo-3,5-dimethylphenol 
• 107-30-2 chloromethyl methyl ether 
• 109-87-5 Dimethoxymethane 

Downstream Products

• 1253118-45-4 3-{[4'-(methoxymethoxy)-2,2',6'-trimethylbiphenyl-3-yl]methoxy}-9H-fluoren-9-one 
• 1253116-99-2 ethyl (3-{[4'-(2-acetoxyethoxy)-2,2',6'-trimethylbiphenyl-3-yl]methoxy}-9H-fluoren-9-yl)acetate 
• 1253117-01-9 sodium (3-{[4'-(2-hydroxyethoxy)-2,2',6'-trimethylbiphenyl-3-yl]methoxy}-9H-fluoren-9-yl)acetate 
• 1607796-21-3 1-(4-methoxymethoxy-2,6-dimethylphenyl)-2,3,3,4,4,5,5-heptafluorocyclopentene 
• 1607796-31-5 3-(2,5-dimethyl-3-thienyl)-4,4,5,5-tetrafluoro-2-(4-hydroxy-2,6-dimethylphenyl)cyclopent-2-enone 
• 1607796-26-8 1-(4-hydroxy-3,5-dimethylphenyl)-2-(2,5-dimethyl-3-thienyl)-3,3,4,4,5,5-hexafluorocyclopentene 
• 1607796-25-7 1-(4-hydroxy-2,6-dimethylphenyl)-2-(2-methyl-5-phenyl-3-thienyl)-3,3,4,4,5,5-hexafluorocyclopentene 
• 1607796-23-5 1-(4-methoxymethoxy-2,6-dimethylphenyl)-2-(2,5-dimethyl-3-thienyl)-3,3,4,4,5,5-hexafluorocyclopentene 
• 1607796-22-4 1-(4-methoxymethoxy-2,6-dimethylphenyl)-2-(2-methyl-5-phenyl-3-thienyl)-3,3,4,4,5,5-hexafluorocyclopentene 
• 906623-28-7 3,5-dimethyl-4-(pyridin-4'-yl)phenol 
• 906623-22-1 4-[4-(methoxymethoxy)-2,6-dimethylphenyl]pyridine 
• 1253118-53-4 ethyl (3-{[4'-(2-acetoxyethoxy)-2,2',6'-trimethylbiphenyl-3-yl]methoxy}-9H-fluoren-9-ylidene)acetate 
• 1253118-50-1 ethyl (3-{[4'-(methoxymethoxy)-2,2',6'-trimethylbiphenyl-3-yl]methoxy}-9H-fluoren-9-ylidene)acetate 
• 1000414-17-4 (4-(methoxymethoxy)-2,6-dimethylphenyl)boronic acid 

Relevant academic research and scientific papers

CARBOXYLIC ACID COMPOUND

[Problem] The present invention has an object to provide a compound having a GPR40 agonistic activity, which is useful as a pharmaceutical composition, an insulin secretion promoter, or an agent for preventing/treating diabetes. [Means for Solution] The present inventors have extensively studied a compound having a GPR40 agonistic activity, and as a result, they have found that the compound (I) of the present invention or a pharmaceutically acceptable salt thereof, in which a carboxylic acid is bonded to a bicyclic or tricyclic moiety through methylene, and further, a benzene ring substituted with a monocyclic 6-membered aromatic ring is bonded to a bicyclic or tricyclic moiety through —O-methylene or —NH-methylene, has an excellent GPR40 agonistic activity. They have also found that the compound has an excellent insulin secretion promoting action and strongly inhibits increase in the blood glucose after glucose loading, thereby completing the present invention.

FUSED CYCLIC COMPOUNDS

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof. The compound or a salt thereof or a prodrug thereof has a GPR40 receptor function modulating action and is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.

Syntheses of sterically hindered pyridinium phenoxides as model compounds in nonlinear optics

Noncentrosymmetric molecules with a π-conjugated system and, among them, push-pull molecules such as pyridinium phenoxide, are a promising new class of materials for applications in optoelectronics due to their nonlinear optical (NLO) properties. Modelling studies have indicated that an increase in the twist angle between the two aromatic rings leads to an enhancement of the NLO properties. In order to confirm this feature experimentally, it was necessary to prepare a series of new hindered pyridinium phenoxides. Their efficient syntheses by Suzuki cross-coupling reactions are described herein. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.