906648-70-2Relevant academic research and scientific papers
Direct sp3 C-H acroleination of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with nucleophilic catalysis
Feng, Zhu-Jia,Xuan, Jun,Xia, Xu-Dong,Ding, Wei,Guo, Wei,Chen, Jia-Rong,Zou, You-Qua,Lu, Liang-Qiu,Xiao, Wen-Jing
, p. 2037 - 2040 (2014)
Sequence catalysis merging photoredox catalysis (PC) and nucleophilic catalysis (NC) has been realized for the direct sp3 C-H acroleination of N-aryl-tetrahydroisoquinoline (THIQ). The reaction was performed under very mild conditions and afforded products in 50-91% yields. A catalytic asymmetric variant was proved to be successful with moderate enantioselectivities (up to 83 : 17 er).
