906652-90-2Relevant academic research and scientific papers
An efficient synthesis of 4,6-diarylnicotinonitrile-acetamide hybrids via 1,2,3-triazole linker as multitarget microbial inhibitors
El-Sayed, Hassan A.,Moustafa, Ahmed H.,Masry, Asmaa A.,Amer, Atef M.,Mohammed, Samar M.
, p. 275 - 285 (2021/10/21)
An efficient and smart approach for design and synthesis of a novel series of nicotinonitrile-1,2,3-triazole-acetamide hybrids was described. The synthetic methodology was commenced with preparation of acetylene derivatives via alkynylation of 2-oxonicotinonitrile with propargyl bromide under mild basic catalyst (pot. carbonate). The facile click cycloaddition reaction of alkynes 2a-f and azido-acetamides 3-5 in the presence of catalytic Cu(I) in H2O/tetrahydrofuran (THF) was utilized for the synthesis of target molecules 6a-l. Triazoles 6c, d, f, and 6i have highly activity against the four pathogenic bacteria (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus) and two pathogenic fungi (Candida albicans and Aspergillus flavus) with minimum inhibitory concentration (MIC) in between 0.5 and 4?μg/ml for bacteria and 0.5 and 8?μg/ml for fungi.
Synthesis and antitumor evaluation of some new thiazolopyridine, nicotinonitrile, pyrazolopyridine, and polyhydroquinoline derivatives using ceric ammonium nitrate as a green catalyst
Fouad, Sawsan A.,Hessein, Sadia A.,Raslan, Reham R.,Shmiess, Nadia A. M.
, (2021/12/23)
A novel series of thiazolo[5,4-b]pyridine, polysubstituted pyridines, pyrazolo [3,4-b] pyridine-5-carbonitriles, and polyhydroquinoline were synthesized via one-pot reaction of 2-iminothiazolidin-5-one, acetyl pyridine, pyrazolone, and/or cyclohexanone wi
Synthesis and biological evaluation of 2-oxonicotinonitriles and 2-oxonicotinonitrile based nucleoside analogues
Abou-Elkhair, Reham A.I.,Moustafa, Ahmed H.,Haikal, Abdelfattah Z.,Ibraheem, Ahmed M.
, p. 388 - 397 (2014/02/14)
Drug resistance and emergence of new pathogens highlight the need for developing new therapeutic agents. We focused on 2-oxonicotinonitrile (2-ONN) as derivative of the natural product 2-pyridinone.1 Herein, we describe the synthesis of 2-ONNs
Preparation of some fused pyridopyrimidine and pyridothienotriazine derivatives for biological evaluation
Rashad,Sayed,Shamroukh,Awad
, p. 2767 - 2777 (2007/10/03)
Compounds 2 and 9 were formed using 3-(4-chloro-phenyl)-1-pyridin-2-yl propenone (1) and malononitrile or ethyl cyanoacetate, respectively. The pyridine derivative 2 was in turn used as a precursor for the preparation of some pyridopyrimidine and fused py
