906673-54-9

Basic information

• Product Name: 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile
• Synonyms: 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile
• CAS NO: 906673-54-9
• Molecular Formula: C₁₄H₈BrNO₂
• Molecular Weight: 251.24
• EINECS: -0
• Mol File: 906673-54-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 441.9±35.0 °C(Predicted)
• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile(906673-54-9)
• EPA Substance Registry System: 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile(906673-54-9)

Safety Data

• Hazardous Substances Data: 906673-54-9(Hazardous Substances Data)

Usage

Uses

4-(4-Bromo-3-formyl-phenoxy)-benzonitrile can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Upstream product

• 1194-02-1 4-fluorobenzonitrile 
• 2973-80-0 2-bromo-5-hydroxybenzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 122-46-3 3-acetoxytoluene 
• 108-39-4 3-methyl-phenol 
• 20035-32-9 4-bromo-3-hydroxy-benzaldehyde 
• 1217366-74-9 4-[4-bromo-3-(1,3-dioxolan-2-yl)phenoxy]benzonitrile 

Downstream Products

• 906673-24-3 AN₂₇₂₈ 
• 906673-45-8 4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile 

Relevant articles and documents

Preparation method of 5-(4-cyanophenoxy)-2, 3-dihydro-1-hydroxy-2, 1-benzoxaborole intermediate

The invention discloses a preparation method of 5-(4-cyanophenoxy)-2, 3-dihydro-1-hydroxy-2, 1-benzoxaborole intermediate. The 5-(4-cyanophenoxy)-2, 3-dihydro-1-hydroxy-2, 1-benzoxaborole intermediatecomprises a structure as shown in a formula IV. The pre

Synthesizing method of 4-(4-bromo-3-aldehyde-phenoxyl)-benzonitrile

The invention provides a synthesizing method of 4-(4-bromo-3-aldehyde-phenoxyl)-benzonitrile. The synthesizing method comprises the following steps of using 3-methylphenol as the starting raw material, and reacting with acid anhydride to prepare 3-methyl-benzene ester; enabling the 3-methyl-benzene ester and sulfonyl chloride to react, so as to prepare a mixture of 3-chloromethyl-benzene ester and3-dichloromethyl-benzene ester; adding ulotropine, and hydrolyzing, so as to obtain 3-hydroxyl-benzaldehyde; performing brominating reaction, so as to obtain 4-bromo-3-hydroxyl-benzaldehyde; adding 4-fluorobenzonitrile, and performing condensation reaction, so as to obtain the 4-(4-bromo-3-aldehyde-phenoxyl)-benzonitrile. The synthesizing method has the advantages that the prices of the reactionraw materials are low, the obtaining is easy, the reaction steps are fewer, the production cost is low, the technology is simple, the product purity is high and reaches 99.0% or above, and the synthesizing method is suitable for industrialized production.

PROCESS FOR PREPARATION OF CRISABOROLE

The present invention relates to a process for the preparation of crisaborole, the process comprising reacting a compound of formula IIa with a compound of formula III to give a compound of formula IV and converting the compound of formula IV to crisaborole. The present invention also relates to a process for the preparation of crystalline crisaborole.