906794-87-4Relevant academic research and scientific papers
Highly regioselective DABCO-catalyzed nucleophilic aromatic substitution (SNAr) reaction of methyl 2,6-dichloronicotinate with phenols
Shi, Yao-Jun,Humphrey, Guy,Maligres, Peter E.,Reamer, Robert A.,Williams, J. Michael
, p. 309 - 312 (2006)
Exclusive formation of 6-aryloxy ethers 9 from an SNAr reaction of methyl 2,6-dichloronicotinate (2) with phenols 7 catalyzed by 1,4-diazabicyclo[2.2.2]octane (DABCO) in the presence of stoichiometric triethylamine is described. The reaction pr
COMPOUND OF 5-HYDROXYL-1,7-NAPHTHYRIDINE SUBSTITUTED BY ARYLOXY OR HETEROOXY, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF
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Paragraph 0051, (2018/02/28)
The present invention relates to a compound of 5-hydroxyl-1,7-naphthyridine substituted by aryloxy or heteroaryloxy, a preparation method thereof and a pharmaceutical use thereof. In particular, the compound has the following Formula (I), wherein R2
NOVEL CRYSTALLINE SALT FORM OF AN ANTIDIABETIC COMPOUND
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Page/Page column 5-8, (2008/12/08)
A novel crystalline anhydrous toluenesulfonic acid salt form of a selective PPAR gamma partial agonist which has a fused bicyclic aromatic group attached to an oxypropanoic acid moiety is stable and non-hygroscopic. The crystalline salt form is useful for
ANTIDIABETIC OXAZOLIDINEDIONES AND THIAZOLIDINEDIONES
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Page/Page column 25, (2008/06/13)
Pyridinyloxyphenyl and pyridinyloxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dy
NOVEL CRYSTALLINE FORMS OF ANTIDIABETIC COMPOUNDS
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Page/Page column 6-8, (2008/06/13)
A novel crystalline anhydrate of the free acid and a crystalline anhydrous besylate salt of a selective PPAR gamma partial agonist which has a fused bicyclic aromatic group attached to an oxypropanoic acid moiety are stable and non-hygroscopic. The compou
FUSED AROMATIC COMPOUNDS HAVING ANTI-DIABETIC ACTIVITY
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Page/Page column 51, (2010/11/23)
Fused aromatic compounds of Formula (I) are PPAR gamma agonists or partial agonists and are useful in the treatment or control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obes
