906795-53-7

Upstream product

• 501-53-1 benzyl chloroformate 
• 402564-07-2 1-[3-C-aminomethyl-2-O-(tert-butyldimethylsilyl)-3-deoxy-5-O-(4-methoxytrityl)-β-D-ribo-pentofuranosyl]uracil 

Downstream Products

• 661485-46-7 acetic acid 1-[3-(benzyloxycarbonylamino-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-2-nitro-ethyl ester 
• 661485-45-6 [4-(tert-butyl-dimethyl-silanyloxy)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-(1-hydroxy-2-nitro-ethyl)-tetrahydro-furan-3-ylmethyl]-carbamic acid benzyl ester 
• 661485-48-9 3'-[N-(benzyloxycarbonyl)aminomethyl]-2'-O-tert-butyldimethylsilyl-5'-carboxy-5',3'-dideoxyuridine 
• 661485-47-8 3'-[N-(benzyloxycarbonyl)aminomethyl]-2'-O-tert-butyldimethylsilyl-5',3'-dideoxy-5'-nitromethyluridine 
• 661485-44-5 3'-[N-(benzyloxycarbonyl)aminomethyl]-2'-O-tert-butyldimethylsilyl-3'-deoxyuridine 

Relevant academic research and scientific papers

Toward amide-modified RNA: Synthesis of 3′-aminomethyl-5′- carboxy-3′,5′-dideoxy nucleosides

Recent discovery of RNA interference has reinvigorated the interest in chemically modified RNA. Chemical approaches may be used to optimize properties of small interfering RNAs, such as thermal stability, cellular delivery, in vivo half-life, and pharmaco