906797-57-7Relevant academic research and scientific papers
Novel intermediate of Iclaprim as well as preparation method and application thereof
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Paragraph 0053-0060, (2020/01/08)
The invention provides a new intermediate compound (formula I) of a dihydrofolate reductase inhibitor Iclaprim. According to the method and the intermediate compound shown as the formula I, the initial raw materials are easy to obtain and low in price, each step of reaction in the whole reaction step route is easy to control, the generation of impurities can be reduced, the obtained intermediate is solid and does not need to be purified, the total yield is high, and the production cost is greatly reduced.
