Phosphodiesterase II, a member of the PDE superfamily, is an enzyme that exists as a dimer and consists of a N-terminal regulatory domain, C-terminal prenylated domain, and a Zn2+ containing catalytic domain. The bovine spleen PDE2 has a molecular weight of 65 kDa and requires divalent cations for its enzymatic activity, with an optimum pH of 7.5.
9068-54-6
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Basic information
- Product Name: PHOSPHODIESTERASE II
- Synonyms: IUB: 3.1.16.1;EC 3.1.16.1;EC 3.1.16.1 TYPE I-SA;EXONUCLEASE I, E COLI;EXONUCLEASE I;3'-EXONUCLEASE TYPE I-SA;SPLEEN EXONUCLEASE;SPLEEN PHOSPHODIESTERASE TYPE I-SA
- CAS NO:9068-54-6
- Molecular Formula:
- Molecular Weight: 0
- EINECS: 232-965-0
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: PHOSPHODIESTERASE II(CAS DataBase Reference)
- NIST Chemistry Reference: PHOSPHODIESTERASE II(9068-54-6)
- EPA Substance Registry System: PHOSPHODIESTERASE II(9068-54-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9068-54-6(Hazardous Substances Data)
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9068-54-6 Usage
Uses
Used in Molecular Biology Research:Phosphodiesterase II is used as a research tool for characterizing polynucleotide chain length, base composition, and identity of terminal nucleotide. It aids in understanding the structure and function of nucleic acids.
Used in DNA Repair Studies:
Phosphodiesterase II is employed in the excision of pyridyloxobutyl (POB) base adducts from DNA, which is crucial for studying DNA repair mechanisms and their implications in various diseases.
Used in DNA Hydrolysis:
In conjunction with micrococcal endonuclease, Phosphodiesterase II is used for hydrolyzing purified DNA to 3'-nucleoside monophosphates, which is essential for various molecular biology techniques and applications.
Biochem/physiol Actions
Phosphodiesterase (PDE) breaks phosphodiester bonds. 3-Isobutyl-methylxanthine (IBMX) is a potential PDE2 inhibitor.Check Digit Verification of cas no
The CAS Registry Mumber 9068-54-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,6 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.Calculate Digit Verification of CAS Registry Number 9068-54:
(6*9)+(5*0)+(4*6)+(3*8)+(2*5)+(1*4)=116
116 % 10 = 6
So 9068-54-6 is a valid CAS Registry Number.
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PHOSPHODIESTERASE II
