90696-34-7Relevant academic research and scientific papers
NEW SYNTHESIS OF 4-ACETOXY-2-AZETIDINONES BY USE OF ELECTROCHEMICAL OXIDATION
Mori, Miwako,Kagechika, Katsuji,Sasai, Hiroaki,Shibasaki, Masakatsu
, p. 531 - 540 (2007/10/02)
4-Acetoxy-2-azetidinone was synthesized from 4-carboxy-2-azetidinone by Kolbe-type electrolysis.Optically pure 4-acetoxy-3--2-azetidinone, which is an important intermediate for the synthesis of thienamycin, and (+)-PS-5 were synthesized by use of this method.
NEW SYNTHESIS OF 4-ACETOXY-2-AZETIDINONES BY USE OF ELECTROCHEMICAL OXIDATION
Mori, Miwako,Kagechika, Katsuji,Tohjima, Koh,Shibasaki, Masakatsu
, p. 1409 - 1412 (2007/10/02)
Optically pure 4-acetoxy-3--2-azetidinone(1b), which is a highly versatile intermediate for the synthesis of thienamycin(2) and other biologically active β-lactam analogs, was synthesized from 4-carboxy-3--2-azetidinone(18) by Kolbe-type electrolysis.
N-Trimethylsilyl Imines: Applications to the Synthesis of β-Lactams
Ha, Deok-Chan,Hart, David J.,Yang, Teng-Kuei
, p. 4819 - 4825 (2007/10/02)
Ester enolates and N-trimethylsilyl imines react to afford N-protio-β-lactams.The stereochemical course of the reaction depends on the ester enolate geometry.Therefore (E)-enolates give mainly cis β-lactams while (Z)-enolates give nearly equal mixtures of cis and trans β-lactams.The use of ethyl β-hydroxybutyrate as the ester component allows the preparation of β-lactams of potential use in carbapenem synthesis.The differences in the behavior of N-trimethylsilyl and N-aryl imines in ester-imine condensations are also discussed.
