90714-71-9Relevant academic research and scientific papers
SYNTHESIS OF ISOSELENAZOLE AND ITS 3- AND 5-SUBSTITUTED DERIVATES
Lucchesini, F.,Bertini, V
, p. 931 - 934 (1984)
A new method of synthesis for isoselenazole and its 3- and 5-subsituted derivates by one-pot procedure which uses α-acetylenic aldehydes or ketones besides hydroxylamine-O-sulphonic acid and potassium selenide in buffered aqueous solution, is described.Wh
Synthesis of Isoselenazoles and Isothiazoles from Demethoxylative Cycloaddition of Alkynyl Oxime Ethers
Zhang, Zhu-Zhu,Chen, Rong,Zhang, Xiao-Hong,Zhang, Xing-Guo
, p. 632 - 642 (2020/12/22)
A general method for the synthesis of isoselenazoles and isothiazoles has been developed by the base-promoted demethoxylative cycloaddition of alkynyl oxime ethers using the cheap and inactive Se powder and Na2S as selenium and sulfur sources. This transformation features the direct construction of N-, Se-, and S-containing heterocycles through the formation of N-Se/S and C-Se/S bonds in one-pot reactions with excellent functional group tolerance.
Synthesis method of isoselenazole derivative
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Paragraph 0037, (2020/12/31)
The invention relates to a synthesis method of an isoselenazole derivative, which comprises the following steps: by using alkynyl oxime ether as a reaction substrate, selenium powder as a selenium source, 1, 8-diazabicyclo undec-7-ene as an alkali and N-methylpyrrolidone as a solvent, carrying out stirring reaction at 120 DEG C for 10-15 hours. The method has the advantages of simple and easily available raw materials, relatively mild reaction conditions, wide substrate universality, novel preparation process, less pollution, low energy consumption and the like.
