9072-41-7 Usage
Description
Motilin (Human, Porcine) is a polypeptide hormone that plays a crucial role in regulating gastrointestinal motility. It is released in the small intestine and into the general circulation during fasting, stimulating gastric motility and promoting the movement of food through the digestive system. In isolated rabbit duodenal segments, porcine motilin has been shown to induce phasic contractions and acetylcholine release from enteric neurons, making it a significant component in the regulation of gastrointestinal function.
Uses
Used in Pharmaceutical Industry:
Motilin (Human, Porcine) is used as a therapeutic agent for increasing gastrointestinal motility in patients with diabetic gastroparesis. It is often used in combination with erythromycin, an antibiotic and agonist at the motilin receptor, to enhance its effectiveness in treating this condition.
Used in Research and Development:
Motilin (Human, Porcine) is also utilized in research and development for studying the mechanisms of gastrointestinal motility and the role of motilin in various physiological processes. This helps scientists and researchers to better understand the function of motilin and develop new treatments for gastrointestinal disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 9072-41-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,7 and 2 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 9072-41:
(6*9)+(5*0)+(4*7)+(3*2)+(2*4)+(1*1)=97
97 % 10 = 7
So 9072-41-7 is a valid CAS Registry Number.
9072-41-7Relevant articles and documents
MOTILIN-LIKE PEPTIDE COMPOUND HAVING TRANSMUCOSAL ABSORBABILITY IMPARTED THERETO
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Paragraph 0059; 0060; 0061; 0062; 0063; 0064, (2017/11/04)
The present invention aims at providing motilin-like peptide compounds that maintain the gastrointestinal motility stimulating activity of native motilin and which are adapted to have higher absorbability upon transmucosal administration. Motilin derivatives were designed and synthesized in consideration of the pathway for the degradation of motilin at a site of its transmucosal absorption and the maintenance of motilin's physiological activity and compounds characterized by substitutions for the amino acid at position 21 of native motilin have been found to show higher absorbability upon transmucosal administration and yet maintain the same activity as motilin.
