Alcohol oxidase (AOX, EC 1.1.3.13) is a flavoenzyme, an oxidoreductase that catalyzes the oxidation of alcohol to the corresponding carbonyl compound and simultaneously releases hydrogen peroxide. It is an enzyme with the highest affinity for methanol and plays a major role in the metabolism of methanol, resulting in the formation of formaldehyde. Alcohol oxidase has been detected in several genera of yeasts, such as Candida, Pichia, and Hansenula, that utilize methanol as a sole carbon and energy source. Primarily localized in the peroxisome, it has also been found in the cytoplasm. Monomers are synthesized in the cytosol and assembled into octomers in the peroxisome, with octomerization thought to be chaparone mediated.
9073-63-6
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Basic information
- Product Name: Oxidase, alcohol
- Synonyms: Alc.oxidase; Alcohol oxidase; E.C. 1.1.3.13; Ethanol oxidase
- CAS NO:9073-63-6
- Molecular Formula: C10H25NO2
- Molecular Weight: 191.311
- EINECS: 232-971-3
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: vacuum-dried powder
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Oxidase, alcohol(CAS DataBase Reference)
- NIST Chemistry Reference: Oxidase, alcohol(9073-63-6)
- EPA Substance Registry System: Oxidase, alcohol(9073-63-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9073-63-6(Hazardous Substances Data)
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9073-63-6 Usage
Uses
Used in Study of Protein Translocation into Peroxisomes:Alcohol oxidase is used as a model enzyme for studying protein translocation into peroxisomes. It helps researchers understand the mechanisms and processes involved in protein transport and localization within the cell.
Used in Methanol Metabolism Studies in Yeasts:
Alcohol oxidase is used as a catalyst in the study of methanol metabolism in yeasts, such as Candida, Pichia, and Hansenula. It aids in understanding the metabolic pathways and the role of alcohol oxidase in the conversion of methanol to formaldehyde.
Used in Bacterial Expression and Immunological Verification of cDNA Clones:
Alcohol oxidase from Pichia pastoris (Product A2404) is used for bacterial expression and immunological verification of Hv-p68 cDNA clones. This application helps in the study and characterization of specific proteins and their functions.
Used as a Lyophilized Powder for Research Purposes:
Alcohol oxidase from Candida boidinii (Product A6941) is provided as a lyophilized powder, which can be used in various research applications, including the study of enzyme kinetics, enzyme inhibition, and the development of new methods for alcohol oxidation.
Reactions
In enzymology, an alcohol oxidase (EC 1.1.3.13) is an enzyme that catalyzes the chemical reaction a primary alcohol + O2 ? an aldehyde + H2O2. Thus, the two substrates of this enzyme are primary alcohol and O2, whereas its two products are aldehyde and H2O2. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor.Biochem/physiol Actions
Alcohol oxidase has the highest affinity for methanol. The affinity decreases with increasing chain length of the alkyl (R) group. Alcohol oxidase is primarily localized in the peroxisome but is also found in the cytoplasm .Check Digit Verification of cas no
The CAS Registry Mumber 9073-63-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,7 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.Calculate Digit Verification of CAS Registry Number 9073-63:
(6*9)+(5*0)+(4*7)+(3*3)+(2*6)+(1*3)=106
106 % 10 = 6
So 9073-63-6 is a valid CAS Registry Number.
9073-63-6Upstream product
9073-63-6Downstream Products
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Oxidase, alcohol
