90734-71-7

Basic information

• Product Name: 1-(6-CHLOROIMIDAZO[1,2-B]PYRIDAZIN-3-YL)-ETHANONE
• Synonyms: 1-(6-CHLOROIMIDAZO[1,2-B]PYRIDAZIN-3-YL)-ETHANONE;3-Acetyl-6-chloroimidazo[1,2-b]pyridazine;1-{6-chloroiMidazo[1,2-b]pyridazin-3-yl}ethan-1-one
• CAS NO: 90734-71-7
• Molecular Formula: C₈H₆ClN₃O
• Molecular Weight: 195.61
• EINECS: 200-001-2
• Mol File: 90734-71-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.502g/cm3
• Refractive Index: 1.688
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.81±0.30(Predicted)
• CAS DataBase Reference: 1-(6-CHLOROIMIDAZO[1,2-B]PYRIDAZIN-3-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-CHLOROIMIDAZO[1,2-B]PYRIDAZIN-3-YL)-ETHANONE(90734-71-7)
• EPA Substance Registry System: 1-(6-CHLOROIMIDAZO[1,2-B]PYRIDAZIN-3-YL)-ETHANONE(90734-71-7)

Safety Data

• Hazardous Substances Data: 90734-71-7(Hazardous Substances Data)

Usage

Uses

3-Acetyl-6-chloroimidazo[1,2-b]pyridazine is a chemical reagent used in the synthesis of pharmaceuticals. Used in the preparation of pyridazine based compounds as treatments for Alzheimers, Parkinson’s and other neurodegenerative diseases.

InChI:InChI=1/C8H6ClN3O/c1-5(13)6-4-10-8-3-2-7(9)11-12(6)8/h2-4H,1H3

Upstream product

• 598-31-2 1-bromoacetone 
• 35053-55-5 N'-(6-chloropyridazin-3-yl)-N,N-dimethylmethanimidamide 
• 78-95-5 chloroacetone 

Downstream Products

• 1264837-95-7 (rac)-4-{3-[1-(5,7-difluoro-quinolin-6-yl)-ethyl]-imidazo[1,2-b]pyridazin-6-yl}-1-phenylpiperazin-2-one 
• 453547-85-8 (4-imidazo[1,2-b]pyridazin-3-yl-pyrimidin-2-yl)-phenyl-amine 
• 453548-65-7 1-(imidazo[1,2-b]pyridazin-3-yl)ethanone 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS

The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

A 2-amino-thiazole compounds (by machine translation)

The present invention relates to the technical field of pharmaceutical chemistry, particularly relates to a 2-amino thiazole compound or its pharmaceutically acceptable salts, its preparation method, and pharmaceutical compositions containing such compounds and its application in the preparation of antineoplastic. (by machine translation)

HETEROCYCLIC OXIME COMPOUNDS

The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).