90736-66-6Relevant academic research and scientific papers
Oxidation of 1-Benzyl-3,4-dihydroisoquinolines Using Active Manganese Dioxide
Amaravathi, M.,Kumari, L. Krishna,Pardhasaradhi, M.
, p. 1246 - 1247 (2007/10/02)
Oxidation of 1-benzyl-3,4-dihydroisoquinolines (I, IV-VII) by active MnO2 affords the corresponding 1-benzoyl-3,4-dihydroisoquinolines in yields >80percent, except in the case of VI which gives the oxidation product in 46percent yield.
Synthesis and Photo-oxygenation of Some Substituted 1-Benzyl-3,4-dihydroisoquinolines. Mechanism of Enamine Photo-oxygenation
Martin, Ned H.,Jefford, Charles W.
, p. 762 - 774 (2007/10/02)
The synthesis of a series of substituted 1-benzyl-3,4-dihydroisoquinolines by Bischler-Napieralski cyclization is described.Competitive methylene blue sensitized photo-oxygenation experiments allowed the determination of relative rates of photo-oxygenation of 1-benzyl-3,4-dihydroisoquinolines.Substituents were shown to affect both the equilibrium concentration of the tautomeric enamine and the overall photo-oxygenation rate.After correcting for differences in enamine concentration, the relative rate data provided a diagnostic probe of the reaction mechanism, which involves transfer of charge in the rate-limiting step.
