ALPHA2,3-(N)-SIALYLTRANSFERASE, also known as α-2,3-sialyltransferase, is an enzyme that catalyzes the transfer of sialic acid (SAs) to the terminal position of glycoproteins and glycolipids. It plays a crucial role in the biosynthesis of complex carbohydrates and the regulation of various biological processes, including cell-cell interactions, immune responses, and cell signaling.
Source:
ALPHA2,3-(N)-SIALYLTRANSFERASE is typically found in various organisms, including bacteria, viruses, and mammals.
Production Methods:
The production of ALPHA2,3-(N)-SIALYLTRANSFERASE can be achieved through recombinant DNA technology, where the gene encoding the enzyme is inserted into a suitable expression system, such as bacteria or yeast, to produce the enzyme in large quantities.
Source:
ALPHA2,3-(N)-SIALYLTRANSFERASE is typically found in various organisms, including bacteria, viruses, and mammals.
Production Methods:
The production of ALPHA2,3-(N)-SIALYLTRANSFERASE can be achieved through recombinant DNA technology, where the gene encoding the enzyme is inserted into a suitable expression system, such as bacteria or yeast, to produce the enzyme in large quantities.
9075-81-4
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Basic information
- Product Name: ALPHA2,3-(N)-SIALYLTRANSFERASE
- Synonyms: ALPHA2,6-(N)-SIALYLTRANSFERASE;ALPHA2,6-NST;ALPHA2,3-(N)-SIALYLTRANSFERASE;ALPHA2,3-(N)-SIALYLTRANSFERASE, RAT;ALPHA2,3-NST;2,6-SIALYLTRANSFERASE;BETA-D-GALACTOSYL-BETA1,3/4-N-ACETYL-BETA-D-GLUCOSAMINE-ALPHA2,3-SIALYLTRANSFERASE;BETA-D-GALACTOSYL-BETA1,4-N-ACETYL-BETA-D-GLUCOSAMINE-ALPHA2,6-SIALYLTRANSFERASE
- CAS NO:9075-81-4
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 9075-81-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -70°C
- Solubility: N/A
- CAS DataBase Reference: ALPHA2,3-(N)-SIALYLTRANSFERASE(CAS DataBase Reference)
- NIST Chemistry Reference: ALPHA2,3-(N)-SIALYLTRANSFERASE(9075-81-4)
- EPA Substance Registry System: ALPHA2,3-(N)-SIALYLTRANSFERASE(9075-81-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 9075-81-4(Hazardous Substances Data)
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9075-81-4 Usage
Uses
Used in Biopharmaceutical Industry:ALPHA2,3-(N)-SIALYLTRANSFERASE is used as a biocatalyst for the synthesis of sialylated glycoconjugates, which are essential for the development of biopharmaceuticals, such as therapeutic proteins and vaccines. The enzyme helps to improve the stability, half-life, and efficacy of these biopharmaceuticals by adding sialic acid residues to their glycan structures.
Used in Cancer Research:
ALPHA2,3-(N)-SIALYLTRANSFERASE is employed in cancer research to study the role of altered sialylation patterns in tumor progression, metastasis, and immune evasion. Understanding the function of this enzyme in cancer biology can lead to the development of novel therapeutic strategies targeting sialylation pathways.
Used in Glycomics Research:
ALPHA2,3-(N)-SIALYLTRANSFERASE is utilized in glycomics research to investigate the structure and function of sialylated carbohydrates in various biological systems. This enzyme aids in the elucidation of the complex glycosylation patterns and their impact on cellular processes and disease mechanisms.
Used in Diagnostic Applications:
ALPHA2,3-(N)-SIALYLTRANSFERASE can be used in diagnostic applications to develop assays for the detection and quantification of sialylated antigens, which can serve as biomarkers for various diseases, including cancer and infectious diseases.
Used in Drug Delivery Systems:
ALPHA2,3-(N)-SIALYLTRANSFERASE can be employed in the development of targeted drug delivery systems, where sialylated glycoconjugates can be used as carriers for the specific delivery of therapeutic agents to diseased cells or tissues, minimizing side effects and enhancing treatment efficacy.
Biochem/physiol Actions
The terminal step of complex?N-glycan biosynthesis is catalysed by α-2,6-sialyltransferase (STs). Bacterial α(2,6)-STs possesses broader acceptor substrate specificity when compared to eukaryotic α(2,6)-STs.Check Digit Verification of cas no
The CAS Registry Mumber 9075-81-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,7 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.Calculate Digit Verification of CAS Registry Number 9075-81:
(6*9)+(5*0)+(4*7)+(3*5)+(2*8)+(1*1)=114
114 % 10 = 4
So 9075-81-4 is a valid CAS Registry Number.
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ALPHA2,3-(N)-SIALYLTRANSFERASE
