907545-27-1

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-chloro-5-methyl-1,3-thiazole-4-carboxylate is used as a key reactant for the preparation of bicyclic octahydrocyclopenta-pyrrolo, which is an antagonist of retinol-binding protein 4 (RBP4). This antagonist has the potential to mitigate further neurodegeneration, making it a promising candidate for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's.
In addition to its role in the synthesis of RBP4 antagonists, Ethyl 2-chloro-5-methyl-1,3-thiazole-4-carboxylate may also be utilized in the development of other therapeutic agents targeting different biological pathways and diseases. Its unique chemical structure allows for further functionalization and modification, enabling the creation of novel compounds with diverse pharmacological properties.

Upstream product

• 72054-60-5 2-amino-5-methylthiazole-4-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS

Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3, and Q are defined herein.

IMIDAZOLE CARBONYL COMPOUND

To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.