907564-67-4Relevant articles and documents
Amide and Peptide Bond Formation in Water at Room Temperature
Gabriel, Christopher M.,Keener, Megan,Gallou, Fabrice,Lipshutz, Bruce H.
, p. 3968 - 3971 (2015)
A general and environmentally responsible method for the formation of amide/peptide bonds in an aqueous micellar medium is described. Use of uronium salt (1-cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylaminomorpholinocarbenium hexafluorophosphate (COMU) as a coupling reagent, 2,6-lutidine, and TPGS-750-M represents mild conditions associated with these valuable types of couplings. The aqueous reaction medium is recyclable leading to low E Factors.