907606-06-8Relevant academic research and scientific papers
Cooperative catalysis in glycosidation reactions with o-glycosyl trichloroacetimidates as glycosyl donors
Geng, Yiqun,Kumar, Amit,Faidallah, Hassan M.,Albar, Hassan A.,Mhkalid, Ibrahim A.,Schmidt, Richard R.
, p. 10089 - 10092 (2013)
Thiourea mediates cooperative glycosidation through hydrogen bonding. N,N′-Diarylthiourea as cocatalyst enforces an SN2-type acid-catalyzed glycosidation even at room temperature (see scheme; Bn=benzyl). From O-(α-glycosyl) trichloroacetimidates as glycosyl donors and various acceptors, β-glycosides are preferentially or exclusively obtained.
