90769-68-9Relevant academic research and scientific papers
Low-valent titanium-mediated stereoselective alkylation of allylic alcohols
Lysenko, Ivan L.,Kim, Keunho,Hyung, Goo Lee,Jin, Kun Cha
supporting information; body text, p. 15997 - 16002 (2009/05/15)
We have developed low-valent titanium-mediated 1,3-transpositive cross-coupling reactions of acyclic and cyclic allylic alcohols for the stereoselective introduction of ethyl, 2-silylethyl, 2-phenethyl, and alkenyl groups. Cross-coupling of an allylic alcohol with a vinylsilane or styrene derivative is particularly noteworthy, as an efficient cross-selective coupling of two alkenes has been elusive. The stereochemistry of the cross-coupling alkylation is consistent with syn addition/β-elimination.
