90775-10-3

Usage

Uses

Used in Pharmaceutical Industry:
(S)-A-BROMO-A-(4-METHYL PHENYL)-ACETONITRIL is used as a key intermediate for the synthesis of various pharmaceuticals due to its unique structural features that facilitate the creation of diverse organic compounds. The presence of the bromine atom allows for further functionalization and modification, making it a valuable precursor in drug development.
Used in Agrochemical Industry:
In the agrochemical sector, (S)-A-BROMO-A-(4-METHYL PHENYL)-ACETONITRIL serves as a building block for the preparation of a range of agrochemicals. Its ability to form complex molecules makes it instrumental in the development of new pesticides and other agricultural chemicals.
Used in Organic Synthesis:
(S)-A-BROMO-A-(4-METHYL PHENYL)-ACETONITRIL is utilized as a versatile intermediate in organic synthesis for the production of a wide array of compounds, including chiral molecules and heterocycles. Its structural components make it a preferred choice for chemists working on complex organic reactions and molecule constructions.
Used in Fine Chemicals Production:
This chemical is also valuable in the production of fine chemicals, where its unique properties are harnessed to create high-quality specialty chemicals used across various industries, including but not limited to pharmaceuticals, fragrances, and flavorings.

Upstream product

• 4815-10-5 2-hydroxy-2-(4-methylphenyl)acetonitrile 
• 2947-61-7 (4-methylphenyl)acetonitrile 

Downstream Products

• 65551-45-3 N-benzyl amino-(4-methylphenyl)acetonitrile 
• 14271-73-9 4-methylbenzoyl cyanide 
• 174574-62-0 C₁₉H₁₆ClN₃O₄ 
• 219487-87-3 C₂₆H₂₃ClN₄O₃ 
• 219487-65-7 N-Benzyl-N-(cyano-p-tolyl-methyl)-2-nitro-benzamide 
• 219487-74-8 2-Amino-N-benzyl-N-(cyano-p-tolyl-methyl)-benzamide 

Relevant academic research and scientific papers

Enantioselective Mannich-Type Reactions to Construct Trifluoromethylthio-Containing Tetrasubstituted Carbon Stereocenters via Asymmetric Dual-Reagent Catalysis

An approach to construct tetrasubstituted carbon stereocenters bearing both a trifluoromethylthio (SCF3) group and a cyano group has been realized, through asymmetric organophosphine-catalyzed Mannich-type reactions. The products were obtained

Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines

Among the different PLA2s identified to date, the group IIA secretory PLA2 (sPLA2 GIIA) is implied in diverse pathological conditions. In this work we describe the synthesis, inhibitory activities, and structure-activity relationships (SAR) of a new class of substituted piperazine derivatives. The in vitro fluorimetric assay using two groups of enzymes, GIB and GIIA, revealed several compounds as highly potent inhibitors (IC50 = 0.1 μM). The in vivo activity assessed by ip or per os administration in a carrageenan-induced edema test in rats showed that two compounds proved to be as potent as indomethacin (10 mg/kg).

A synthetic route to [1,2,4]triazolo[1,5-a][4,1]benzoxazepines

A reaction sequence leading to the new title compounds is described, the key step of which is an intramolecular cycloaddition of nitrilimine to a nitrile group.