90794-98-2Relevant articles and documents
Simple and convenient synthesis method of N9-alkylate nucleoside analogs on purine framework
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Paragraph 0075; 0076; 0077; 0078; 0079; 0080, (2018/03/26)
The invention discloses a simple and convenient synthesis method of N9-alkylate nucleoside analogs on a purine framework. The method comprises the following steps that 2,6-site substituted purine derivatives and excessive alkyl ether are added into a reactor; next, non-metallic catalysts and oxidizing agents are added; oxidization coupling reaction is performed under the heating and stirring conditions; thin layer chromatography is used for tracking the reaction; after the reaction is completed, the materials are cooled to the room temperature; vacuum concentration is performed to remove solvents; column chromatography purification is performed; the N9-alkylate nucleoside analogs on the purine framework are obtained. The synthesis method provided by the invention has the advantages that the raw materials are cheap and can be easily obtained; the reaction conditions are mild; the reaction steps are few; the operation is simple; the problems of easy poisoning by metal catalysts, compatibility difficulty of active groups and many reaction sites in the purine derivatization reaction in the prior art are solved; the N9-alkylate nucleoside analogs on the purine framework can be efficiently synthesized.
