907958-40-1Relevant academic research and scientific papers
Synthesis of novel fluorinated derivatives of 1,3-dimethylbarbituric acid
Xu, Yuelian,Dolbier Jr., William R.
, p. 6319 - 6328 (2007/10/03)
Synthetic utility of the novel difluoro ketene aminal 1 was extended to the preparation of a number of potentially biologically-interesting difluoro barbituric acid derivatives via initial hetero-Diels-Alder reactions of 1 with p-substituted-5-benzylidene-1,3-dimethylbarbituric acids 3. These cycloadducts 4 upon hydrolysis, provided the formal Michael addition product amides 5 which were readily converted to the respective carboxylic acids 6. The acids were dehydratively cyclized to form novel bicyclic lactones 8.
