90799-75-0Relevant academic research and scientific papers
Azidothymidine "clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors
Berrino, Emanuela,Angeli, Andrea,Zhdanov, Dmitry D.,Kiryukhina, Anna P.,Milaneschi, Andrea,De Luca, Alessandro,Bozdag, Murat,Carradori, Simone,Selleri, Silvia,Bartolucci, Gianluca,Peat, Thomas S.,Ferraroni, Marta,Supuran, Claudiu T.,Carta, Fabrizio
, p. 7392 - 7409 (2020)
Cancer cells rely on the enzyme telomerase (EC 2.7.7.49) to promote cellular immortality. Telomerase inhibitors (i.e., azidothymidine) can represent promising antitumor agents, although showing high toxicity when administered alone. Better outcomes were o
