907991-20-2

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 907991-19-9 (R)-1-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-3-methyl-piperazine 
• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 75336-86-6 (2R)-methylpiperazine 
• 907991-13-3 (R)-1-(5-chloro-2-nitrophenyl)-3-methylpiperazine 
• 610-40-2 3,4-dinitro-chlorobenzene 
• 696-63-9 4-Methoxybenzenethiol 
• 907991-18-8 (R)-4-[5-Chloro-2-(4-methoxy-phenylsulfanyl)-phenyl]-2-methyl-piperazine-1-carboxylic acid benzyl ester 
• 907991-16-6 (R)-4-(5-Chloro-2-iodo-phenyl)-2-methyl-piperazine-1-carboxylic acid benzyl ester 
• 907991-15-5 (R)-4-(2-Amino-5-chloro-phenyl)-2-methyl-piperazine-1-carboxylic acid benzyl ester 
• 907991-14-4 (R)-4-(5-Chloro-2-nitro-phenyl)-2-methyl-piperazine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

An improved synthesis of Lu AA20465

A solution phase synthesis for the preparation of the glycine transporter 1 (GlyT1) inhibitor Lu AA20465 is presented, which relies on the straightforward assembly of the target molecule through a series of innovative reaction steps. The key steps include a regioselective amination reaction, a chemoselective reduction of an aryl nitro group, a diazotization and iodination sequence under nonaqueous conditions and a copper catalyzed thioarylation reaction.