908006-11-1

Basic information

• Product Name: 2-chloro-4-[(3-cyanophenyl)amino]-8-methyl-6-(methylthio)-3-quinolinecarboxamide
• Synonyms: 2-chloro-4-[(3-cyanophenyl)amino]-8-methyl-6-(methylthio)-3-quinolinecarboxamide
• CAS NO: 908006-11-1
• Molecular Weight: 382.873
• Mol File: 908006-11-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-[(3-cyanophenyl)amino]-8-methyl-6-(methylthio)-3-quinolinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-[(3-cyanophenyl)amino]-8-methyl-6-(methylthio)-3-quinolinecarboxamide(908006-11-1)
• EPA Substance Registry System: 2-chloro-4-[(3-cyanophenyl)amino]-8-methyl-6-(methylthio)-3-quinolinecarboxamide(908006-11-1)

Safety Data

• Hazardous Substances Data: 908006-11-1(Hazardous Substances Data)

Upstream product

• 908006-10-0 2,4-dichloro-6-iodo-8-methyl-3-quinolinecarboxamide 
• 17314-32-8 tributyl(methylthio)stannane 

Downstream Products

• 908006-12-2 2-chloro-4-[(3-cyanophenyl)amino]-8-methyl-6-(methysulfonyl)-3-quinolinecarboxamide 

Relevant articles and documents

Addressing species specific metabolism and solubility issues in a quinoline series of oral PDE4 inhibitors

Species specific conversion of the lead PDE4 inhibitor 1 to the quinolone 3 was identified as the major route of metabolism in the cynomolgus monkey. Modification of the template to give the cinnoline 9 retained potency and selectivity, and greatly improved the pharmacokinetic profile in the cynomolgus monkey compared with 1. Additional SAR studies aimed at improving the solubility of 9 are also described.