908070-89-3Relevant academic research and scientific papers
Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation
Wright, Christine M.,Chovatiya, Raj J.,Jameson, Nora E.,Turner, David M.,Zhu, Guangyu,Werner, Stefan,Huryn, Donna M.,Pipas, James M.,Day, Billy W.,Wipf, Peter,Brodsky, Jeffrey L.
, p. 3291 - 3301 (2008/09/19)
The Hsp70 molecular chaperones are ATPases that play critical roles in the pathogenesis of many human diseases, including breast cancer. Hsp70 ATP hydrolysis is relatively weak but is stimulated by J domain-containing proteins. We identified pyrimidinone-
A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process
Werner, Stefan,Turner, David M.,Lyon, Michael A.,Huryn, Donna M.,Wipf, Peter
, p. 2334 - 2338 (2007/10/03)
A second generation focused library of 30 tetrahydropyrimidinone amides was prepared. The design was based on the structure of an Hsp70 modulator. This small library demonstrates the utility of tandem multi-component reactions in structure-activity relati
