90808-83-6

Upstream product

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• 126-81-8 dimedone 
• 71885-49-9 3,3-dimethyl-glutaric acid monoethyl ester 
• 802294-64-0 propionic acid 
• 104426-30-4 (4E)-3,3-dimethyl-4-hexenoic acid 
• 17123-68-1 4,4-dimethylhept-6-en-2-one 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 926-20-5 2,4-dimethyl-2,6-heptadien-4-ol 
• 4325-82-0 4-methyl pent-3-en-2-ol 
• 1777-31-7 3,3-dimethyl-hex-4t-enal 
• 3917-18-8 2-methyl-4-vinyloxy-pent-2-ene 
• 64-17-5 ethanol 
• 116169-12-1 ethyl 3,3-dimethylhexanoate 

Relevant academic research and scientific papers

Development of a catalytic enantioselective conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes for the synthesis of endothelin-A antagonist ABT-546. Scope, mechanism, and further application to the synthesis of the antidepressant rolipram

The enantioselective synthesis of endothelin-A antagonist ABT-546 has been accomplished via the discovery and development of a highly selective catalytic asymmetric conjugate addition of ketoesters to nitroolefins. Employing just 4 mol % bis(oxazoline)-Mg

Stereoselective process for producing nitro compounds

The present invention relates to producing stereoselective nitro compounds by reacting a dicarbonyl compound with a nitrostyrene compound in the presence of a catalyst complex and a base.

Synthesis and Hypolipidemic and Antidiabetogenic Activities of β,β,β',β'-Tetrasubstituted, Long-Chain Dioic Acids

β,β,β',β'-Tetrasubstituted, long-chain dioic acids of the general formula HOOC-C(XY)-C(R2)-Q-C(XY)-COOH have been synthesized and evaluated as hypotriglyceridemic-hypocholesterolemic agents in rats and as antidiabetogenic agents in ob/ob diabetic mice.The free carboxyl function of analogues of the series was mandatory for their hypolipidemic-antidiabetogenic effect while nonhydrolyzable diesters were inactive.Other structure-activity relationships were determined as a function of the overall chain length (C12-C22), α,α'-substitutions (X,Y=H,F,Cl,Br,OH,CN), β,β'-substitutions (R=CH3,C6H5), and core substitutions 2, 1,4-C6H42, 1,4-C6H4(CH=CHCH2)2, CH2(OCH2CH2)3OCH2)>.The most effective hypolipidemic-antidiabetogenic members of the series were α,α'-nonsubstituted, β,β'-methyl-substituted analogues of 14-18-carbon chains having either a saturated aliphatic core or a 1,4-bis(propenyl)benzene core in the cis/trans configuration.The hypotriglyceridemic rather than the hypocholesterolemic capacity of members of the series was found to correlate with their respective capacities as liver peroxisomal proliferation in rats.