908119-67-5Relevant academic research and scientific papers
Halogen-metal exchange/cyclization of iodoketones: A direct synthesis of 3-arylbenzofurans
Kraus, George A.,Schroeder, Jacob D.
, p. 2504 - 2506 (2005)
The first synthesis of benzofuran 2 was achieved in 17% overall yield in seven steps. The key step was a halogen-metal exchange/cyclization reaction. Several examples of this reaction were reported. Georg Thieme Verlag Stuttgart.
Nickel-Catalyzed Intramolecular Nucleophilic Addition of Aryl Halides to Aryl Ketones for the Synthesis of Benzofuran Derivatives
Zhu, Xiao-Rui,Deng, Chen-Liang
supporting information, p. 1842 - 1848 (2021/02/09)
A nickel-catalyzed intramolecular nucleophilic addition reaction of aryl halides to aryl ketones for the formation of benzofuran derivatives has been developed. A number of substrates bearing electron-donating or electron-withdrawing groups were subjected to the standard reaction conditions, giving the corresponding products in moderate to good yields.
Nickel-Catalyzed Asymmetric Addition of Aromatic Halides to Ketones: Highly Enantioselective Synthesis of Chiral 2,3-Dihydrobenzofurans Containing a Tertiary Alcohol
Li, Ying,Li, Wendian,Tian, Jiangyan,Huang, Guozheng,Lv, Hui
supporting information, p. 5353 - 5357 (2020/07/14)
A highly enantioselective and straightforward synthetic procedure to chiral 3-hydroxy-2,3-dihydrobenzofurans has been developed by nickel/bisoxazoline-catalyzed intramolecular asymmetric addition of aryl halides to unactivated ketones, giving 2,3-dihydrobenzofurans with a chiral tertiary alcohol at the C-3 position in good yields and excellent enantioselectivities (up to 92percent yield and 98percent ee). The gram-scale reaction also proceeded smoothly without a loss of yield and enantioselectivity.
Simple N-Heterocyclic Carbenes as Ligands in Ullmann-Type Ether and Thioether Formations
Wu, Jiang-Ping,Saha, Anjan K.,Haddad, Nizar,Busacca, Carl A.,Lorenz, Jon C.,Lee, Heewon,Senanayake, Chris H.
supporting information, p. 1924 - 1928 (2016/07/06)
A simple N-heterocyclic carbene (NHC) derived from 1-methyl-3-ethylimidazolium tetrafluoroborate was found to be an efficient ligand for a range of copper-catalyzed cross-coupling reactions, leading to the formation of aromatic ethers and thioethers. (Figure presented.) .
tert-BuOK-mediated carbanion-yne intramolecular cyclization: Synthesis of 2-substituted 3-benzylbenzofurans
Chen, Po-Yuan,Wang, Tzu-Pin,Huang, Keng-Shiang,Kao, Chai-Lin,Tsai, Jui-Chi,Wang, Eng-Chi
experimental part, p. 9291 - 9297 (2011/12/02)
A mild, efficient, and regioselective carbanion-yne intramolecular cyclization mediated by t-BuOK for the synthesis of 2-substituted 3-benzylbenzofurans is developed. It was started from o-iodophenol (1), based on O-alkylation, and the Sonogashira reaction in sequence to produce 2-(2-phenylethynylphenoxy)-1-arylalkanones (5). An intramolecular carbanion-yne 5-exo-dig cyclization reaction of 5, which was mediated by t-BuOK, yielded title benzofurans in good yields.
Palladium(II)-catalyzed intramolecular addition of arylboronic acids to ketones
Liu, Guixia,Lu, Xiyan
, p. 7324 - 7330 (2008/12/20)
A palladium(II)-catalyzed intramolecular addition of arylboronic acids to ketones was developed. Compared to Pd(OAc)2 catalysis system, cationic palladium complex with dppp as the ligand has higher catalytic activity and efficiency for wider sc
Cationic palladium complex catalyzed highly enantioselective intramolecular addition of arylboronic acids to ketones. A convenient synthesis of optically active cycloalkanols
Liu, Guixia,Lu, Xiyan
, p. 16504 - 16505 (2007/10/03)
An efficient and convenient synthesis of optically active cycloalkanols by utilizing the chiral cationic palladium complex as the catalyst was achieved in mild conditions with high yield and high enantioselectivity. Copyright
