908123-79-5Relevant academic research and scientific papers
Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists
Cole, Andrew G.,Stroke, Ilana L.,Brescia, Marc-Raleigh,Simhadri, Srilatha,Zhang, Joan J.,Hussain, Zahid,Snider, Michael,Haskell, Christopher,Ribeiro, Sofia,Appell, Kenneth C.,Henderson, Ian,Webb, Maria L.
, p. 200 - 203 (2006)
The identification and evaluation of aryl-[1,4]diazepane ureas as functional antagonists of the chemokine receptor CXCR3 are described. Specific examples exhibit IC50 values of ~60 nM in a calcium mobilization functional assay, and dose-dependently inhibit CXCR3 functional response to CXCL11 (interferon-inducible T-cell α chemoattractant/I-TAC) as measured by T-cell chemotaxis, with a potency of approximately 100 nM.
