908141-27-5Relevant academic research and scientific papers
Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR
Menear, Keith A.,Gomez, Sylvie,Malagu, Karine,Bailey, Christine,Blackburn, Kristel,Cockcroft, Xiao-Ling,Ewen, Sally,Fundo, Alexandra,Gall, Armelle Le,Hermann, Gesine,Sebastian, Luisa,Sunose, Mihiro,Presnot, Thomas,Torode, Eleanor,Hickson, Ian,Martin, Niall M.B.,Smith, Graeme C.M.,Pike, Kurt G.
scheme or table, p. 5898 - 5901 (2010/08/22)
A pharmacophore mapping approach, derived from previous experience of PIKK family enzymes, was used to identify a hit series of selective inhibitors of the mammalian target of rapamycin (mTOR). Subsequent refinement of the SAR around this hit series based
