908141-95-7 Usage
Uses
Used in Research on Parkinson's Disease:
4-(2-hydrazinopyrimidin-4-yl)morpholine is used as a neurotoxin in the creation of animal models for Parkinson's disease. It serves as a crucial tool for understanding the pathophysiology of the condition and for evaluating the efficacy of potential treatments. 4-(2-hydrazinopyrimidin-4-yl)morpholine's ability to mimic Parkinson's disease symptoms provides researchers with a controlled environment to study the progression of the disease and the impact of various interventions on its symptoms.
Used in Drug Development:
In the pharmaceutical industry, 4-(2-hydrazinopyrimidin-4-yl)morpholine is used as a reference compound in the development of drugs aimed at treating Parkinson's disease. Its role in inducing Parkinson's-like symptoms allows researchers to assess the effectiveness of new drugs in mitigating the damage caused by the neurotoxin and in restoring dopamine levels in the brain.
Used in Toxicology Studies:
4-(2-hydrazinopyrimidin-4-yl)morpholine is also used in toxicology research to study the effects of neurotoxins on the central nervous system. Its impact on mitochondrial function and dopaminergic neurons provides insights into the mechanisms of neurotoxicity and contributes to the development of strategies for neuroprotection.
Due to the highly toxic nature of MPTP, its use is strictly regulated in research settings, and it is not employed in any clinical treatments. The primary application of 4-(2-hydrazinopyrimidin-4-yl)morpholine lies in advancing scientific understanding of Parkinson's disease and in the development of more effective therapeutic approaches.
Check Digit Verification of cas no
The CAS Registry Mumber 908141-95-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,8,1,4 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 908141-95:
(8*9)+(7*0)+(6*8)+(5*1)+(4*4)+(3*1)+(2*9)+(1*5)=167
167 % 10 = 7
So 908141-95-7 is a valid CAS Registry Number.
908141-95-7Relevant academic research and scientific papers
Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis
Wu, Xiaoai,Fang, Zhen,Yang, Bo,Zhong, Lei,Yang, Qiuyuan,Zhang, Chunhui,Huang, Shenzhen,Xiang, Rong,Suzuki, Takayoshi,Li, Lin-Li,Yang, Sheng-Yong
supporting information, p. 2284 - 2288 (2016/04/20)
Herein we report the discovery of a series of new KDM5A inhibitors. A three-dimensional (3D) structure model of KDM5A jumonji domain was firstly established based on homology modeling. Molecular docking-based virtual screening was then performed against c
