90820-03-4Relevant articles and documents
The discovery of novel calcium sensing receptor negative allosteric modulators
Balan, Gayatri,Bauman, Jonathan,Bhattacharya, Samit,Castrodad, Mayda,Healy, David R.,Herr, Michael,Humphries, Paul,Jennings, Sandra,Kalgutkar, Amit S.,Kapinos, Brendon,Khot, Vishal,Lazarra, Kimberly,Li, Mei,Li, Yan,Neagu, Constantin,Oliver, Robert,Piotrowski, David W.,Price, David,Qi, Hong,Simmons, Holly A.,Southers, James,Wei, Liuqing,Zhang, Yan,Paralkar, Vishwas M.
scheme or table, p. 3328 - 3332 (2010/05/19)
The design and profile of a series of zwitterionic calcium sensing receptor negative allosteric modulators is described. Evaluation of key analogues using a rat model demonstrate a robust response, significantly improved potency over ronacaleret and have