90824-73-0Relevant academic research and scientific papers
Access to indoles via Diels-Alder reactions of 2-vinylpyrroles with maleimides
Noland, Wayland E.,Lanzatella, Nicholas P.,Venkatraman, Lakshmanan,Anderson, Nicholas F.,Gullickson, Glen C.
experimental part, p. 1154 - 1176 (2010/03/04)
(Chemical Equation Presented) Variously substituted 2-vinylpyrroles underwent an endo-addition [4+2] cycloaddition reaction with maleimides followed by a spontaneous highly diastereoselective (93-98% de) isomerization to give tetrahydroindoles in moderate to excellent yield. Treatment with activated MnO2 in refluxing toluene provided the corresponding indoles in moderate to good yield. This highly convergent methodology for formation of indoles is versatile and the starting materials are conveniently prepared.
Biocatalytic cleavage of alkenes with O2 and Trametes hirsuta G FCC 047
Lara, Miguel,Mutti, Francesco G.,Glueck, Silvia M.,Kroutil, Wolfgang
supporting information; experimental part, p. 3668 - 3672 (2009/05/07)
Alkenes possessing a C=C double bond adjacent to an aromatic ring were cleaved to yield the corresponding carbonyl compounds by use of molecular oxygen as the sole oxidant and a cell-free extract of the wood-degrading fungus Trametes hirsuta FCC 047 as catalyst. The oxygen pressure required was optimized. Special adapted equipment allowed 96 reactions to be performed in parallel under controlled oxygen pressure. A broad spectrum of aryl-alkenes was successfully converted into the corresponding ketones/aldehydes with excellent chemoselectivity under a controlled oxygen atmosphere (2 bar). Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
