908296-35-5Relevant academic research and scientific papers
BENZAMIDE COMPOUND
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Page/Page column 65, (2008/06/13)
A compound represented by the general formula (I) or a salt thereof, a solvate of the compound or the salt, or a prodrug thereof: (I) wherein R1 represents a fat-soluble group, R2 represents an acidic group, R3 represents a hydrogen atom or a C1-6 alkyl group, W represents a bond or a spacer having 1 to 10 atoms in its main chain which may have a substituent, A represents a spacer having 1 to 6 atoms in its main chain which may have a substituent, (ring 1) represents a cyclic group which may have a substituent, and p represents an integer of 1 to 5, provided that a plurality of fat-soluble groups represented by R1 are the same as or different from one another when p is 2 or more. The compound or salt thereof, the solvate of the compound or the salt or the prodrug thereof has remarkably improved EP3 antagonistic activity and is useful as an agent for treatment and/or prevention of a skin diseases, pain, urogenital disease, neuropsychiatric disease, artery obstructive disease or inflammatory disease or threatened premature labor.
