90832-25-0Relevant academic research and scientific papers
Michael addition of N-isobutylidene-t-butylamine to dimethyl methoxymethylenemalonate and a new synthesis of some fused pyrazole derivatives from the adduct
Ito,Ihara,Miyajima
, p. 1529 - 1532 (1993)
N-Isobutylidenemethylamine reacted with dimethyl methoxymethylenemalonate to afford the N-alkylation product 3a exclusively. Exchanging the N- substituent of the Schiff's base from methyl to t-butyl altered the course of the reaction, allowing Michael addition to take place predominantly. The Michael adduct 4c on reaction with hydrazinoalkanols 6a,b, 6c,d and 6e gave tetrahydropyrazolo[5,1-b]oxazoles 9a,b, tetrahydropyrazolo[5,1- b][1,3]oxazines 9c,d and hexahydropyrazolo[5,1-b][1,3]oxazepine 9e, respectively.
Reduction of β-Lactams, I. Reduction of 3,3,3',3'-Tetramethyl-2,2'-dione with Complex Hydrides
Verkoyen, Carl,Rademacher, Paul
, p. 1659 - 1670 (2007/10/02)
Reduction of the title compound 7 with lithium aluminium hydride leads to four products 8 to 11 in yields depending on the reaction conditions.Compounds 8 to 10 are also obtained from the bicyclic hydrazide 12, isomeric with 7.Therefore, the reduction of 7 and 12 is likely to proceed in part via common intermediates.A reaction scheme is proposed to account for the generation of the products.With other hydride reagents comlex reaction mixtures are obtained from 7.The reduction of 7 to 3,3,3',3'-tetramethyl-1,1'-biazetidine (13) failed.
