90834-06-3Relevant academic research and scientific papers
A mechanistic deviation in the Bischler indole synthesis
Sanchez-Viesca,Gomez,Berros, Martha
, p. 367 - 372 (2003)
When α-bromo-2,4,5-trimethoxybutyrophenone reacted with p-toluidine, the unexpected 3,5-dimethyl-2-(2,4,5-trimethoxybenzyl)indole was obtained. This mechanistic deviation was also observed with α -bromo-2,4,5-trimethoxyvalerophenone and α -bromo-2,4,5-tri
Synthesis and hypolipidemic activity of modified side chain α-asarone homologues
Cruz,Garduno,Salazar,Martinez,Jimenez-Vazquez,Diaz,Chamorro,Tamariz
, p. 535 - 544 (2007/10/03)
A series of homologues of α-asarone (1), containing variable size and functionality on the side chain attached to the aromatic ring, has been subjected to a study of structure-activity relationship. For most of the prepared derivatives, either with a carbonyl (8a-8e), a hydroxy group (9a-9e), or with a conjugated double bond (10a-10d), significant effects on serum lipoprotein cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides were displayed. The results showed an enhancement of the hypocholesterolemic activity as the length of the chain is decreased. Theoretical conformational and electrostatic potential analyses of 1 and olefins 10 suggest unfavorable steric interactions in the bulky superior side-chain homologues as the deactivating biological effect.
