908340-53-4Relevant articles and documents
Novel antibacterial class: A series of tetracyclic derivatives
Hinman, Mira M.,Rosenberg, Teresa A.,Balli, Darlene,Black-Schaefer, Candace,Chovan, Linda E.,Kalvin, Douglas,Merta, Philip J.,Nilius, Angela M.,Pratt, Steve D.,Soni, Niru B.,Wagenaar, Frank L.,Weitzberg, Moshe,Wagner, Rolf,Beutel, Bruce A.
, p. 4842 - 4856 (2006)
We describe the synthesis and antibacterial activity of a series of tetracyclic naphthyridones. The members of this series act primarily via inhibition of bacterial translation and belong to the class of novel ribosome inhibitors (NRIs). In this paper we