908371-49-3Relevant academic research and scientific papers
Development of a scalable and safe procedure for the production of (3R)-3-(2,3-dihydro-1-benzofuran-5-yl)-1,2,3,4-tetrahydro-9H-pyrrolo[3,4-b] -quinolin-9-one, an intermediate in the synthesis of PDE-V inhibitors RWJ387273 (R301249) and RWJ444772 (R290629
Willemsens, Bert,Vervest, Ivan,Ormerod, Dominic,Aelterman, Wim,Fannes, Christine,Mertens, Narda,Marko, Istvan E.,Lemaire, Sebastien
, p. 1275 - 1281 (2006)
A scalable and safe process for the oxidative rearrangement of β-carboline to quinolone derivatives, intermediates in the synthesis of PDE-V inhibitors RWJ387273 (R301249) and RWJ444772 (R290629), has been developed.
AN EFFICIENT AND STEREOSELECTIVE PROCESS FOR LARGE SCALE SYNTHESIS OF 3-(R)-3- (2,3-DIHYDROBENZOFURAN-5-YL)-1,2,3,4- TETRAHYDROPYRROLO{3,4-B}QUINOLIN-9-ONE
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Page/Page column 47; 48, (2008/06/13)
This invention relates to an efficient process for large scale stereoselective production of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo{3,4-b}quinolin-9-ones and key intermediates used for the preparation of benzofuranyl pyrroloquinolon
