90844-08-9Relevant academic research and scientific papers
Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of Bryostatin analogs
Wender, Paul A.,Nakagawa,Near, Katherine E.,Staveness, Daryl
supporting information, p. 5136 - 5139 (2015/02/19)
Bryostatin 1 is in clinical trials for the treatment of cancer and Alzheimer's disease and is a candidate for a first-in-class approach to HIV/AIDS eradication. It is neither readily available nor optimally suited for clinical use. Using a function oriented synthesis strategy, a new class of bryostatin-inspired analogs was designed with a simplified salicylate-derived subunit, enabling step-economical synthesis (23 total steps) of agents exhibiting bryostatin-like affinity to protein kinase C (PKC).
NOUVEAUX DERIVES DE LA BENZOPYRANNONE-4, A ACTIVITES ANALGESIQUE, ANTI-INFLAMMATOIRE ET ANTIAGREGANTE PLAQUETTAIRE
Darmanaden, R.,Dhanutirto, H.,Castel, J.,Loubatiere, J.,Flandre, O.
, p. 876 - 887 (2007/10/02)
A series of 35 new derivatives of 3-benzylidene benzopyran-4-one carboxylic acid was synthesized; their antiinflammatory and analgesic activities were investigated and compared with those of acetylsalicylic acid, phenylbutazone, ketoprofene and glafenine.Among these compounds, four were found to be more potent than the references compounds in tests of antiinflammatory and analgesic activity.Seven compounds were tested on rat blood platelet aggregation induced by ADP.From these tests, HD-039, HD-041, HD-044 and HD-049 appear to be promising antiinflammatory, analgesic and anticlotting agents, although this original series shows little structural analogy with classical non-steroidal antiinflammatory agents.
