908590-01-2Relevant academic research and scientific papers
Synthesis and evaluation of the β-turn properties of 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-ones and of their spirocyclic derivative
Van Rompaey, Karolien,Ballet, Steven,Toemboely, Csaba,De Wachter, Rien,Vanommeslaeghe, Kenno,Biesemans, Monique,Willem, Rudolph,Tourwe, Dirk
, p. 2899 - 2911 (2006)
A series of 4-amino-tetrahydro-2-benzazepin-3-one derivatives (Ac-Aba-Xxx-NHMe) were prepared as tetrapeptide mimetics. Considering the structural resemblance with the so-called Freidinger lactams, their propensity to adopt a β-turn conformation was inves
