908595-64-2Relevant academic research and scientific papers
Solvent-free synthesis of novel unsymmetric chenodeoxycholic acid bis thiocarbazone derivatives promoted by microwave irradiation and evaluation of their antibacterial activity
Shi, Zhichuan,Zhao, Zhigang,Liu, Min,Wang, Xiaohong
, p. 977 - 984 (2013)
Eleven new non-symmetric chenodeoxycholic acid bis thiocarbazones were efficiently synthesized via the condensation of steroidal diketones (methyl (5β)-3,7-dioxocholan-24-oate) and substituted benzaldehyde thiocarbohydrazones by means of microwave irradiation. Compared with the conventional heating method, the yields were increased from 31-58% to 80-89% and the reaction times were reduced from 420-520 min to 5.0-7.5 min. The structures of these novel compounds were characterized by spectral data and elemental analysis. Four compounds (7a, 7c, 7f and 7g) possess excellent activity against Bacillus subtilis and Staphylococcus aureus.
Microwave-assisted synthesis and antibacterial activity of unsymmetrical indolyl/aryl bis-thiosemicarbazones
Li, Lin,Jiang, Yujia,Liu, Xingli,Zhao, Zhigang
, p. 372 - 374 (2013/07/26)
A series of nine novel unsymmetrical bis-thiosemicarbazones were prepared in high yield by condensation of aromatic aldehyde thiosemicarbazones with indole-3-carboxaldehyde using microwave irradiation. The structures of the new compounds were characterised. Six of the compounds displayed varying levels of antibacterial activity against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus.
