90860-80-3Relevant academic research and scientific papers
Intramolecular 2H Group-Transfer (Dyotropic Rearrangements) in Alicyclic and Heterocyclic Bridged-Ring Systems
Mackenzie, K.,Proctor, G.,Woodnutt, D. J.
, p. 5981 - 5994 (2007/10/02)
Examples of alicyclic frameworks containing a cyclohexa-1,3-diene ring as 2H donor held proximate to a variously-substituted acceptor Π-bond are compared for their reactivity in thermal 2H group-transfer reactions.Kinetic analysis reveals marked effects on rearrangement-rate as the acceptor Π-bond substituents are varied.Attempted synthesis of exact structural analogues of these compounds but with a 2,3-diazacyclohexadiene component replacing the cyclohexadiene element usually gives instead products of concomitant 2H group-transfer.These results are compared with the similar but generally slower 2H group-transfer rearrangement of pentacyclic 2-pyrazoline derivatives having relevant critical stereochemical features which result from 1,3 -diarylnitrilimine (4+2)Π adductions with dipolarophiles of the isodrin type.Alkoxy and chlorine substitution of the acceptor Π-bond is rate-retarding for 2H group-transfer in both the alicyclic and heterocyclic representative systems examined, indicating truly pericyclic behaviour.
INTRAMOLECULAR 2H GROUP-TRANSFER IN HETEROCYCLIC BRIDGED-RING SYSTEMS (DYOTROPIC REARRANGEMENT)
Mackenzie, K.,Proctor, G. J.,Woodnutt, D. J.
, p. 977 - 980 (2007/10/02)
Diarylnitrilimines, derived by thermolysis of appropriate diaryltetrazoles, form (4+2)? cyclo-adducts with dipolarophiles of isodrin type, e.g. (1); the resulting 2-pyrazolines thermally rearrange into pyrazoles by hydrogen group transfer.Kinetic data for examples of this and related reactions are reported.
