908600-72-6 Usage
Uses
Used in Pharmaceutical Industry:
1H-Indole-5-carboxylic acid, 4-fluorois utilized as a synthetic intermediate for the development of new pharmaceuticals and medicinal compounds. Its unique structure and chemical properties contribute to the creation of novel drug candidates, potentially leading to advancements in various therapeutic areas.
Used in Organic Chemistry:
In the field of organic chemistry, 1H-Indole-5-carboxylic acid, 4-fluoroserves as a key building block for the synthesis of complex organic molecules. Its reactivity and structural features facilitate the construction of a wide range of organic compounds for various applications, including materials science and specialty chemicals.
Used in Drug Discovery Research:
1H-Indole-5-carboxylic acid, 4-fluorois employed in drug discovery research as a potential lead compound. Its biological activities and pharmacological effects are under investigation, with the aim of identifying new therapeutic agents for the treatment of various diseases and conditions.
Used in Medicinal Chemistry:
In medicinal chemistry, 1H-Indole-5-carboxylic acid, 4-fluorois applied as a versatile chemical entity for the design and optimization of drug candidates. Its unique properties and structure enable the development of novel compounds with improved pharmacokinetic and pharmacodynamic profiles, enhancing their potential as therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 908600-72-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,8,6,0 and 0 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 908600-72:
(8*9)+(7*0)+(6*8)+(5*6)+(4*0)+(3*0)+(2*7)+(1*2)=166
166 % 10 = 6
So 908600-72-6 is a valid CAS Registry Number.
908600-72-6Relevant academic research and scientific papers
In search of simplicity and flexibility: A rational access to twelve fluoroindolecarboxylic acids
Schlosser, Manfred,Ginanneschi, Assunta,Leroux, Frederic
, p. 2956 - 2969 (2007/10/03)
All twelve indolecarboxylic acids 1-12 carrying both a fluorine substituent and a carboxy group at the benzo ring have been prepared either directly from the corresponding fluoroindoles 13-16 or from the chlorinated derivatives 22, 23 and 25 by hydrogen/metal permutation ("metalation"), or from the bromo- or iodofluoroindoles 17-20 and 26, 27, 29 and 30 by halogen/metal permutation, the organometallic intermediate being each time trapped with carbon dioxide. In most, though not all cases, the nitrogen atom in the five-membered ring had to be protected by a trialkylsilyl group. Some of the bromo- or iodofluoroindoles (26 and 27) were successfully subjected to a basicity gradient-driven selective migration of the heavy halogen. An unexpected finding on the way to the target compounds were the rigorously site-selective metalation of the 5-fluoro-N-(trialkylsilyl)indole (14b; exclusive deprotonation of the 4-position). The fluoroindoles 13-16, although previously known, were accessed more conveniently from suitably substituted nitrobenzenes using the Bartoli or the Leimgruber-Batcho method. A new and very attractive indole synthesis was elaborated consisting of the ortho-lithiation of an N-acyl-protected aniline followed by ortho-formylation, Wittig chloromethylenation and base-catalyzed cyclization accompanied by dehydrochlorination. These five consecutive steps can be contracted to a convenient one-pot protocol. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
