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Product FOB Price Min.Order Supply Ability Supplier
Trypsin inhibitor,pancreatic basic/ LIDE PHARMA- Factory supply / Best price
Cas No: 9087-70-1
USP/BP/EP API Raw Material Aprotinin CAS#9087-70-1 Aprotinin
Cas No: 9087-70-1
USD $ 7.0-8.0 / Gram 1 Gram 10 Kilogram/Month HANWAYS CHEMPHARM CO.,LIMITED Contact Supplier
Aprotinin EP8.0 manufacture GMP
Cas No: 9087-70-1
No Data 1 Gram Metric Ton/Day Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier
Trypsin inhibitor, pancreatic basic
Cas No: 9087-70-1
USD $ 190.0-200.0 / Milliliter 1 Milliliter 20 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
High quality Aprotinin Cas 9087-70-1 with favorable price
Cas No: 9087-70-1
USD $ 90.0-105.0 / Gram 10 Gram 30 Kilogram/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Factory Supply Aprotinin
Cas No: 9087-70-1
No Data 1 1 Ality Chemical Corporation Contact Supplier
Factory Price API 99% Aprotinin 9087-70-1 GMP Manufacturer
Cas No: 9087-70-1
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Trypsin inhibitor,pancreatic basic Manufacturer/High quality/Best price/In stock
Cas No: 9087-70-1
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Cas No: 9087-70-1
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
tianfu-chem_APT// Aprotinin 9087-70-1
Cas No: 9087-70-1
No Data 1 Kilogram 100 Kilogram/Month Henan Tianfu Chemical Co., Ltd. Contact Supplier

9087-70-1 Usage


Aprotinin is a reversible inhibitor of serine proteases such as trypsin (Ki = 0.06 pM), chymotrypsin (Ki = 9.5 nM), and kallikrein (Ki = 0.8 nM). It is a much weaker inhibitor of thrombin (Ki = 0.1-0.8 mM) and trypsinogen (Ki = 2 μM). Aprotinin also competitively inhibits nNOS and iNOS with Ki values of 50 and 78 μM, respectively. Aprotinin is widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest.

Chemical Properties

white powder




A potent protease inhibitor.Aprotinin acts as a reversible serine protease blocking and a binding agent. It is widely employed as an inhibitor of trypsin. It is also used as a proteolytic inhibitor in radioimmunoassays of polypeptide hormones. It is involved in the purification of urokinase, trypsin, and chymotrypsin on immobilized aprotinin. Further, it is used in the quantification of kallikrein activity in mixtures of esterases and proteases.


Aprotinin is largely used as an inhibitor of trypsin.


Proteolytic inhibitor in radioimmunoassays of polypeptide hormones.

Manufacturing Process

1 kg of parotid of cattle, which were freed of fat and flesh are comminuted in a meat chopper and twice extracted with 5 L of acetone. The acetone was removed as far as possible by sucking off and the moist material is digested for 2.5 hours in 1.2 L of 1 N acetic acid and 2.8 L of 96% ethanol at 50°C. The filtrate containts about 230.000 inactivator units. The alcoholic solution is concentrated to 1.2 L by evaporating in vacuo and shaken with an equal amount of ether. Dark coloring matters and residues of fat are thus dissolved. The aqueous phase is now mixed with acetone until a precipitate occurs and the dissolved in dilute acetic acid. The solution is brought to a weakly alkaline pH by addition of ammonia. It is then centrifuged and the inactivator is precipitated with five times the amount of ethanol. The yield amounts to about 180.000 kallikrein inactivator units in 0.4-0.5 g of substance.

Brand name

Trasylol (Bayer).

Therapeutic Function

Proteinase inhibitor

General Description

Trypsin inhibitor, pancreas type from bovine lung. It is known as Pancreatic trypsin inhibitor (BPTI). Aprotinin, also known as pancreatic trypsin inhibitor and trypsin-kallikrein inhibitor, is found to be expressed in lungs, spleen, liver, and pancreas. It is also found to be present in the free form in calf serum.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Safety Profile

Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx.


1. henry da, carless pa, moxey aj, et al. anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. cochrane database syst rev 2007; 4: cd001886.2. levi m, cromheecke me, de jonge e, et al. pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints. lancet 1999; 354: 1940-7.3. sedrakyan a, treasure t, elefteriades ja. effect of aprotinin on clinical outcomes in coronary artery bypass graft surgery: a systematic review and meta-analysis of randomized

9087-70-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (Y0001154)  Aprotinin for system suitability  European Pharmacopoeia (EP) Reference Standard 9087-70-1 Y0001154 1,880.19CNY Detail
Sigma-Aldrich (A1250000)  Aprotininsolution  BRP, European Pharmacopoeia (EP) Reference Standard 9087-70-1 A1250000 1,880.19CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name Aprotinin

1.2 Other means of identification

Product number -
Other names cas9004-04-0

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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