90872-73-4Relevant academic research and scientific papers
Complex base-induced generation of 3,4-didehydropyridine derivatives: New access to aminopyridines or pyridones
Vinter-Pasquier, Karine,Jamart-Gregoire, Brigitte,Caubere, Paul
, p. 2113 - 2129 (2007/10/03)
The complex base, NaNH2-tert-BuONa, in THF easily transforms 3-bromopyridine and 2-pyridone derivatives into the corresponding hetarynes. The reaction of representative amines (dialkylamines, morpholine, piperidine) with these reactive intermediates leads to the preparation of aminopyridines in good yields and illustrates the synthetic usefulness of such reactions.
NEW APPLICATION OF COMPLEX BASES: NUCLEOPHILIC CONDENSATIONS OF PYRIDINE
Jamart-Gregoire, Brigitte,Leger, Christian,Caubere, Paul
, p. 7599 - 7602 (2007/10/02)
3,4-Dehydropyridine can be easily generated from 3-bromopyridine by complex bases.Nucleophilic condensations of amines, ketones and nitrile enolates are thus performed for the first time in good to very good yields.
