90877-05-7Relevant academic research and scientific papers
2,4,6-Trichloropyrimidine. Reaction with anilines
Schomaker,Delia
, p. 1457 - 1462 (2000)
The reaction of 2,4,6-trichloropyrimidine 1 with a variety of 4-substituted anilines 2 has been investigated. Monosubstitution occurs readily for all anilines except those containing strongly electron-withdrawing groups. The yields of the isomeric product
POTASSIUM CHANNEL MODULATORS
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Paragraph 0123-0124, (2018/01/14)
Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with potassium channels. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with potassium channels.
Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: Inhibitors of lysophosphatidic acid acyltransferase-β
Gong, Baoqing,Hong, Feng,Kohm, Cory,Jenkins, Scott,Tulinsky, John,Bhatt, Rama,De Vries, Peter,Singer, Jack W.,Klein, Peter
, p. 2303 - 2308 (2007/10/03)
2,4-Diamino-N4,6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-β (LPAAT-β). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in
