908856-83-7

Upstream product

• 124156-21-4 ethyl N-(p-methoxyphenyl)iminoacetate 
• 870-63-3 prenyl bromide 
• 104-94-9 4-methoxy-aniline 
• 124156-21-4 ethyl (4-methoxyphenylimino)acetate 
• 50845-77-7 N-(4-methoxy)phenylglycine ethyl ester 
• 865-58-7 3-bromo-3-methyl-but-1-ene 

Downstream Products

• 1400676-93-8 tert-butyl 1-(allyl(phenyl)amino)-3,3-dimethyl-1-oxopent-4-en-2-ylcarbamate 
• 1400676-95-0 tert-butyl 4,4-dimethyl-2-oxo-1-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-ylcarbamate 
• 1400676-99-4 tert-butyl 4,4-dimethyl-2-oxo-1-phenylazepan-3-ylcarbamate 

Relevant academic research and scientific papers

Tin powder-promoted oxidation/allylation of glycine esters: Synthesis of γ,δ-unsaturated α-amino acid esters

An efficient tin powder-promoted oxidation/allylation reaction of glycine esters with allyl bromides is developed, which affords γ,δ-unsaturated α-amino acid esters under mild conditions without any other transition metal catalysts. This method avoids the use of unstable imine as starting material, and provides an efficient method for synthesis of γ,δ-unsaturated α-amino acid esters and α-methylene-γ-lactam derivatives. Additional supporting information may be found in the online version of this article at the publisher's web site.

Indium-assisted aluminium-based stereoselective allylation of prostereogenic α,α-disubstituted cycloalkanones and imines

The use of a catalytic amount of InCl3in combination with Al0for the allylation of a variety of prostereogenic α,α-disubstituted (hindered) cycloalkanones, 1,2-dione-based systems and various imino systems (CN functional groups) is reported. The stereoselective InCl3-catalyzed Al-based allylation of various 2-substituted-2-carbethoxycycloalkanones gave the corresponding products with moderate to excellent diastereoselectivity. The allylation and propargylation of imines including α-imino esters using a catalytic amount of InCl3in combination with Al0gave the corresponding allylated and propargylated compounds in moderate to good yields. If γ-substituted allylic halides were added to imino compounds, low to very good diastereoselectivity was obtained. The allylation of chiral N-tert-butylsulfinyl imine systems gave the corresponding products in moderate yields with good to excellent diastereoselectivity. This journal is

SUBSTITUTED ADIPIC ACID AMIDES AND USES THEREOF

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, wherein A is a five to eight membered monocyclic or a nine to twelve membered bicyclic heterocyclic ring, as further defined herein; Y is S, CH2, or CH; Z is CH or N; R7 and R9 are hydrogen or (C1-C6)alkyl; R2 is (C1 C6)alkoxy, OH, CN, (C1-C6)alkyl, halogen, or CF3; r and s are 0, 1, or 2; and R1 and R3 are as further defined herein. These compounds are agonists, partial agonists and/or modulators of the NPY4 receptor and may be used for the treatment and prophylaxis of obesity, food intake, and other diseases and conditions modulated by the NPY4 receptor.

Compounds and compositions for use in the prevention and treatment of obesity and related syndromes

The invention relates to 4-hydroxyisoleucine, isomers, analogs, lactones, salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. More particularly, the invention relates to the use of those compounds in the prevention and treatment of obesity and related syndromes.